Artwork Courtesy of Katherine Nagel

Selected Publications

Carlile, T. M., Martinez, N. M., Schaening, C. S., Su, A., Bell, T. A., Zinshteyn, B. and Gilbert, W. V. (2019) “mRNA structure determines modification by conserved pseudouridine synthase 1” Nat Chem Biol, in press.

Wang, Y. J., Vaidyanathan, P. V., Rojas-Duran, M. F., Udeshi, N. D., Bartoli, K. M., Carr, S. A., and Gilbert, W. V. (2018) “Lso2 is a conserved ribosome-bound protein required for translational recovery in yeast”. PLoS Biology 16(9), e2005903.

Martinez, N.M. and Gilbert, W.V. (2018) Pre-mRNA modifications and their role in nuclear RNA processing. Quant Biol. 6(3):210-227.

Zinshteyn, B., Rojas-Duran, M. F., and Gilbert, W.V. (2017) “Translation initiation factor eIF4G1 preferentially binds yeast transcript leaders containing conserved oligo-uridine motifs. RNA 23:1365-1375.

Thompson, M. K. and Gilbert, W. V. (2017) “mRNA length-sensing in eukaryotic translation: reconsidering the "closed loop" and its implications for translational control”. Current Genetics 63:613-620.

Cattie, D.J., Richardson, C. E., Reddy, K. C., Ness-Cohn, E. M., Droste, R., Thompson, M. K., Gilbert, W. V., Kim, D. H. “Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in C. elegans”. (2016) PloS Genetics 12 (9): e1006326.

Gould, G. M., Paggi, J. M., Guo, Y., Zinshteyn, B., Wang, E. T., Gilbert, W. V., Gifford, D. K., and Burge, C. B. (2016) “Identification of new branch points and unconventional introns in Saccharomyces cerevisiae”. RNA 22: 1522-1534.

Stanley, S. E., Gable, D. L., Wagner, C. L, Thomas M. Carlile, T. M., Hanumanthu, V. S., Podlevsky, J. D., Sara E. Khalil, S. E., DeZern, A. E., Rojas-Duran, M. F., Carolyn D. Applegate, C. D., Jonathan K. Alder, J. K., Parry, E. M, Gilbert, W. V., and Armanios, M. (2016) “Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema”. Science Translational Medicine 8 (351): 351ra107.

Gilbert, W. V., Bell, T. A., and Schaening, C. S. (2016) “Messenger RNA Modifications – Form, Distribution, and Function”. Science 352:1408-12.

Thompson, M. K., Rojas-Duran, M. F., Gangaramani, P. and Gilbert, W. V. (2016) “The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs”. eLife Apr 27;5. pii: e11154. doi: 10.7554/eLife.11154.

Berchowitz, L. E., Walker, M. R., Kabachinski, G. L., Carlile, T. M., Gilbert, W. V., Schwartz, T. U., Amon, A. (2015) “Regulated formation of an amyloid-like translational repressor governs gametogenesis”. Cell 163 (2): 406-18.

Carlile, T. M., Rojas-Duran, M. F., and Gilbert, W. V. (2015) “Pseudo-Seq: Genome-wide detection of pseudouridine modifications in RNA”. Methods in Enzymology 560: 219-45.

Carlile, T. M., Rojas-Duran, M. F., and Gilbert, W. V. (2015) “Transcriptome-wide identification of pseudouridine modifications using Pseudo-seq”. Current Protocols 112: 4.25.1-4.25.24.

Saha, A., Mitchell, J. A., Nishida, Y., Hildreth, J. E., Arribere, J. A., Gilbert, W. V., and Garfinkel, D. J. (2015) “A trans-dominant form of Gag restricts Ty1 retrotransposition and mediates copy number control". J. Virology 89(7): 3922-38.

Carlile, T. M., Rojas-Duran, M. F., Shin, H., Zinshteyn, B., Bartoli, K. B., and Gilbert, W. V. (2014). “Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells”. Nature 515 (7525): 143-6. Highlighted in Nature Reviews Genetics. Highlighted in Nature Methods. Highlighted in ACS Chemical Biology. Highlighted in Cell Research. Highlighted by the Saccharomyces Genome Database (“New & Noteworthy”).

Vaidyanathan PP, Zinshteyn B, Thompson MK, Gilbert WV. Protein kinase A regulates gene-specific translational adaptation in differentiating yeast. RNA. 2014 Jun;20(6):912-22. doi: 10.1261/rna.044552.114.

Zinshteyn B, Gilbert WV (2013) Loss of a Conserved tRNA Anticodon Modification Perturbs Cellular Signaling. PLoS Genet 9(8): e1003675. doi:10.1371/journal.pgen.1003675

Arribere J.A., Gilbert W.V. Roles for transcript leaders in translation and mRNA decay revealed by Transcript Leader Sequencing. Genome Res. 2013 Apr 11.

Rojas-Duran, M. F., and Gilbert, W. V. Alternative transcription start site selection leads to large differences in translation activity in yeast. RNA. 2012 Oct 25.

Arribere, J. A., Doudna, J. A., and Gilbert, W. V. Reconsidering movement of eukaryotic mRNAs between polysomes and p-bodies. Mol Cell. 2011 Dec 9;44(5):745-58.

Gilbert, W. V. Functional specialization of ribosomes? Trends Biochem Sci., 2011, 36(3):127-32.

Gilbert, W. V. Alternative ways to think about cellular internal ribosome entry. JBC, 2010, 285(38):29033-8.

Coyle, S. M., Gilbert, W. V., and Doudna, J. A. Direct link between RACK1 function and localization at the ribosome in vivo. Mol Cell Biol., 2009, 29(6):1626-34.

Gilbert, W. V., Zhou, K., Butler, T. K. and Doudna, J. A. Cap-independent translation is required for starvation-induced differentiation in yeast. Science, 2007, 317(5842):1224-7.

Gilbert, W. V. and Guthrie, C. The Glc7p nuclear phosphatase promotes mRNA export by facilitating association of Mex67p with mRNA. Mol Cell, 2004, 13(2):201-212.

Gilbert, W. V., Siebel, C. W., and Guthrie, C. Phosphorylation by Sky1p promotes Npl3p shuttling and mRNA dissociation. RNA, 2001, 7:302-313.